Adolescent cannabis use: mapping risk factors and neurodevelopmental trajectories using resting state and white matter connectivity
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The project capitalizes on data from the prestigious longitudinal IMAGEN consortium https://imagen-europe.com/ which comprises longitudinal imaging, cognition, mental health and genetic data on 2000 adolescents examined longitudinally at three assessment times (age 14 years, 16 years, 18 years) with ongoing data collection at age 20 years.
This project will be the first to examine whether
??? neural alterations predate cannabis use onset. To this end, we will (i) compare resting state functional connectivity, white matter connectivity at baseline between adolescents who later initiated cannabis use and those who did not, and (ii) assess predictors of cannabis use onset.
??? trajectories of neurodevelopmental change in those who start and continue cannabis use, relative to those who do not commence using.
??? Specific cannabinoid compounds including delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) measured in cannabis users via hair-analysis and with putative neurotoxic and neuroprotective properties - are associated with resting state functional connectivity and white matter connectivity.
This project has scope for a PhD. I welcome any expressions of interest from national and international research students.
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Supervisors supervising this project
|Dr Valentina Lorenzetti||Principal Supervisor|
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