Dr Nolan Hoffman - Mary MacKillop Institute for Health Research (Faculty of Health Sciences)

Accreditation in-progress - Supervisor is eligible to co-supervise with another fully accredited supervisor (Principal Supervisor)


Dr Nolan Hoffman completed his BSc in Biology at Butler University in his hometown of Indianapolis, Indiana in the USA. Nolan earned his PhD in Cellular and Integrative Physiology in 2012 from Indiana University School of Medicine, where he also received postgraduate training in the business of life sciences. He relocated to Australia in 2012 to undertake his postdoctoral research at the Garvan Institute of Medical Research and the University of Sydney Charles Perkins Centre. He joined Australian Catholic University in 2016 as a Postdoctoral Research Fellow in the Exercise and Nutrition Research Program at the Mary MacKillop Institute for Health Research where he currently leads the Integrative Physiology Group.

Nolan's research is focused on the regulation of whole body and skeletal muscle metabolism by diet and exercise with a focus on cellular signalling networks and energy sensing mechanisms. His translational research involves a range of approaches including molecular biology, cell biology, biochemistry, proteomics, systems biology and physiology.


Phone :(03) 9230 8277 (Melbourne)
Email :Nolan.Hoffman@acu.edu.au
URIs : Staff Directory ProfilePersonal Website

Research Interests

Exercise ; Exercise Metabolism ; Exercise-Nutrition Interactions ; Muscle Physiology ; Type 2 diabetes ;

Methods Expertise

Cell Signalling ; Cell biology ; Muscle physiology and biochemistry ; Carbohydrate, protein and lipid metabolism ; Exercise ;

Research Projects

No research project is currently recorded.

Selected Publications


High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans, in FASEB Journal

Interactive Roles for AMPK and Glycogen from Cellular Energy Sensing to Exercise Metabolism, in International Journal of Molecular Sciences

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice, in Journal of Biological Chemistry

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance, in eLife


Omics and Exercise: Global Approaches for Mapping Exercise Biological Networks, in Cold Spring Harbor Perspectives in Medicine

Metabolomic analysis of insulin resistance across different mouse strains and diets, in Journal of Biological Chemistry


mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3, in Molecular Metabolism

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle, in Molecular Metabolism


PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications, in BMC Genomics

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates, in Cell Metabolism

Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells, in Data in Brief

The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle, in Diabetes

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs, in Molecular & Cellular Proteomics


Structural basis for phosphorylation and lysine acetylation cross-talk in a kinase motif associated with myocardial ischemia and cardioprotection, in Journal of Biological Chemistry

Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation, in Journal of Cellular Physiology

Chromium enhances insulin responsiveness via AMPK, in Journal of Nutritional Biochemistry


Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment, in Diabetologia


AMPK enhances insulin-stimulated GLUT4 regulation via lowering membrane cholesterol, in Endocrinology


Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis, in Trends in Endocrinology and Metabolism