Associate Professor Jon Oakhill - Mary MacKillop Institute for Health Research (Faculty of Health Sciences)
Fully accredited supervisor - Can supervise as principal supervisor
I graduated from the University of Bath, UK (1998) and completed my Ph.D studies (2002) at King???s College London investigating iron acquisition in pathogenic Neisseria meningitidis. My first postdoctoral position uncovered molecular mechanisms and transporters responsible for dietary iron absorption in the duodenum. A move to Bruce Kemp's lab at St. Vincent's Institute, Melbourne in 2006 prompted a change in research fields to energy metabolism.
I formed the Metabolic Signalling Laboratory in 2014, a multi-disciplinary team employing biochemical, biophysical, structural and cell-based techniques to investigate signalling pathways controlling cellular metabolism. While maintaining a core interest in regulation of AMP-activated protein kinase (AMPK), the cellular fuel gauge and a drug target of great potential, we are now expanding our scope to incorporate other central metabolic kinases (e.g. ULK1, mTOR, CaMKK2) and associated pathways. I also lead efforts to develop small-molecule therapeutics targeting AMPK to treat metabolic diseases such as type 2 diabetes, cancer and neurodegeneration.
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- Allosteric regulation of AMPK (PhD) (Principal Supervisor)
- Identifying kinases that target the AMPK drug site (PhD) (Principal Supervisor)
- AMPK inhibition as a therapeutic strategy (PhD) (Principal Supervisor)
AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965, in Journal of Biological Chemistry
Energy sensing through a sugar diphosphate, in Nature
Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release, in Cell Chemical Biology
AMPK functions as an adenylate charge-regulated protein kinase, in Trends in Endocrinology and Metabolism